Gene-Centric Meta-Analysis of Lipid Traits in African, East Asian and Hispanic Populations
نویسندگان
چکیده
Meta-analyses of European populations has successfully identified genetic variants in over 100 loci associated with lipid levels, but our knowledge in other ethnicities remains limited. To address this, we performed dense genotyping of ∼2,000 candidate genes in 7,657 African Americans, 1,315 Hispanics and 841 East Asians, using the IBC array, a custom ∼50,000 SNP genotyping array. Meta-analyses confirmed 16 lipid loci previously established in European populations at genome-wide significance level, and found multiple independent association signals within these lipid loci. Initial discovery and in silico follow-up in 7,000 additional African American samples, confirmed two novel loci: rs5030359 within ICAM1 is associated with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) (p = 8.8×10(-7) and p = 1.5×10(-6) respectively) and a nonsense mutation rs3211938 within CD36 is associated with high-density lipoprotein cholesterol (HDL-C) levels (p = 13.5×10(-12)). The rs3211938-G allele, which is nearly absent in European and Asian populations, has been previously found to be associated with CD36 deficiency and shows a signature of selection in Africans and African Americans. Finally, we have evaluated the effect of SNPs established in European populations on lipid levels in multi-ethnic populations and show that most known lipid association signals span across ethnicities. However, differences between populations, especially differences in allele frequency, can be leveraged to identify novel signals, as shown by the discovery of ICAM1 and CD36 in the current report.
منابع مشابه
Genetic Determinants of Lipid Traits in Diverse Populations from the Population Architecture using Genomics and Epidemiology (PAGE) Study
For the past five years, genome-wide association studies (GWAS) have identified hundreds of common variants associated with human diseases and traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. Approximately 95 loci associated with lipid levels have been identified primarily among populations of European anc...
متن کاملReplication of Caucasian Loci Associated with Osteoporosis-related Traits in East Asians
BACKGROUND Most reported genome-wide association studies (GWAS) seeking to identify the loci of osteoporosis-related traits have involved Caucasian populations. We aimed to identify the single nucleotide polymorphisms (SNPs) of osteoporosis-related traits among East Asian populations from the bone mineral density (BMD)-related loci of an earlier GWAS meta-analysis. METHODS A total of 95 SNPs,...
متن کاملGenome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.
Blood lipid concentrations are heritable risk factors associated with atherosclerosis and cardiovascular diseases. Lipid traits exhibit considerable variation among populations of distinct ancestral origin as well as between individuals within a population. We performed association analyses to identify genetic loci influencing lipid concentrations in African American and Hispanic American women...
متن کاملThe Prevalence of some Intestinal Parasites in Food-Handlers of Asian and African Countries: A Meta-Analysis
Background & Aims of the Study: Parasitic infections are common in many countries, especially in developing countries and tropical areas. People who deal with foods can be a threat to health of communities. This meta-analysis study was undertaken to determine the prevalence of parasitic infections, such as Ascaris lumbricoides, Entamoeba coli, Entamoeba histolytica, and Giardia...
متن کاملارزیابی تنوع ژنتیکی و روابط فیلوژنتیکی مرغان بومی ایران بر مبنای توالی ناحیه D- loop از DNA میتوکندریایی
In the present study for evaluation of genetic variability within and between Iranian native fowls, thirty nine blood samples were randomly collected from native fowls breeding stations of west Azarbayjan, Khorasan, Fars, Mazandaran, Yazd and Esfahan provinces. Inorder to compare the obtained results with other Asian, African and European breeds the D-loop sequences of mtDNA taken from GenBan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 7 شماره
صفحات -
تاریخ انتشار 2012